Aging is a part of life and
comes with the risk of osteoporosis, among other things. Osteoporosis is the
reduction of bone mass, which weakens the bone and can cause
an increased risk of fracture or breaking. On top of osteoporosis, according to
a new article released by science daily, aging promotes the increased
production of ApoE. ApoE,
otherwise known as apolipoprotein E, is a protein that largely interferes with the healing processes of bone. The study points out that 75-85 year olds had twice as much ApoE in their bloodstreams as 35-45 year olds. The mechanism behind inhibition of healing is that when a bone is broken and fractured, cells are recruited to the site and eventually turn into osteoblasts to form bone. ApoE
causes fewer recruited cells to turn into osteoblasts, which leads to
interference of bone healing processes. The study also
stated that “Past research linked ApoE to Alzheimer's disease and atherosclerosis, a disease in which fatty plaques narrow the arteries. Too
little ApoE and fat build up can cause cardiovascular issues.” With this information, researchers are trying
to find a safe level of ApoE that will accommodate the patients' health status.
For more information, visit: https://www.sciencedaily.com/releases/2019/09/190919122512.htm
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